Professor Florida A & M University Tallahassee, Florida
The common approach of prescribing a single transdermal patch for people of different skin types and ages often results in the patch adhesion failure, which reduces its effectiveness in treatment. Objective of the present study was to develop different skin mimetic substrates with similar roughness (e.g. delamination, wrinkles), surface energy and elasticity considering age/sex differences for in vitro adhesion testing including probe tack and peel adhesion tests. Additionally, our aim was to develop personalized Rotigotine patches and assess them to determine how environmental factors, such as temperature and humidity, might cause molecular/chemical changes in the formulations.
Our results showed that the adhesion properties of the Rotigotine patches were significantly affected by difference in the skin conditions including roughness, surface energy and elasticity. Further, we could successfully develop personalized Rotigotine patches with excellent adhesion properties for various skin types. Analysis using solid-state NMR and FTIR techniques indicated that over time, Rotigotine patches absorb moisture, leading to diminished adhesion. Consequently, the incorporation of non-hygroscopic agents such as mannitol and lactose become necessary to enhance moisture protection in patch formulations.
Overall, novel skin mimetic substrates were developed for in vitro adhesion testing of Rotigotine patches, resulting in personalized patches with excellent adhesion properties for different skin types. Our innovative testing method promises improved in vitro-in vivo adhesion performance of transdermal patches.
Learning Objectives:
Understand 3D printing and also the methods to print skin mimetic probes.
Get a better understanding of using techniques like solid state NMR and FT-IR in patch evaluation.
Understand the role of skin roughness, elasticity and surface energy for developing a skin mimetic substrate.
Understanding the role of moisture and humidity in patch failure and demonstrating techniques to overcome that
Use a case study with Rotigotine patch to apply the principles discussed above
