Prologue: The Effect of Excipients on the Colloidal Stability of Monoclonal Antibodies

On Demand

Location:Online Only

Prologue Speaker(s)

Stephen Hoag, PhD

Professor
University of Maryland Baltimore
Baltimore, Maryland

Handouts

Antibody formulations and protein stability are vital for therapeutic applications. Understanding formulation basics and maintaining stability ensures efficacy and safety. To improve formulation outcomes, one needs to understand aggregation mechanisms, which can compromise stability, and are a key formulation challenge. Excipients play a crucial role in stabilizing colloidal stability of proteins, which includes preventing aggregation. This presentation will provide a brief introduction to these topics.

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Learning Objectives:

Upon completion, participants will be able to describe the nature of protein aggregates.
Upon completion, participants will be able to list excipients that are used in mAb formulations and state their function.
Upon completion, participants will be able to describe the aggregation pathway from mAb monomer nucleation, to aggregate growth and finally to an irreversibly aggregated state.