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Formulation and Delivery
Partner Presentation

Improving Content Uniformity of Morphologically Challenging APIs by Excipient Choice

Tuesday, October 22, 2024
9:00 AM – 10:00 AM MT
Location:360 Stage #1, Exhibit Hall

Sponsored By 
Formulation and Delivery Partner Presentation-Formulation

The blending efficacy of co-processed Silicified Microcrystalline Cellulose (PROSOLV® SMCC) has been demonstrated visually, using pigments as a surrogate for the API in the formulation. This study uses Near-Infrared Spectroscopy to demonstrate that efficacy with real data.
Using two blender types, the uniformity of caffeine, a needle-like API with high static charge, was measured when blended with SMCC, or alternatively with a physical blend of its component parts, MCC and colloidal silicon dioxide.

Learning Objectives:

  • Learn how NIRS can be used to quantify uniformity of APIs in blend formulations.
  • Learn how blending pattern can affect API uniformity.
  • Learn how excipient co-processing can affect blending efficacy and tablet performance.