Senior Principal Scientist
Certara UK (Simcyp Division)
SHEFFIELD, United Kingdom
Armin Sepp is a Senior Principal Scientist at Certara Ltd. where he leads the biologics section of Science team, specializing in the physiologically-based pharmacokinetics (PBPK) of biologics. His background in bioorganic chemistry and PhD in enzyme kinetics from Tartu University under the direction of Prof. Jaak Järv provided the perfect foundation for post-doctoral training in protein engineering and in vitro evolution at the MRC Immunochemistry Unit in Oxford and MRC Laboratory of Molecular Biology in Cambridge. Pharmaceutical work started with human domain antibody engineering at Domantis Ltd start-up in Cambridge, followed by GlaxoSmithKline Plc (GSK) where he became Scientific Leader and GSK Fellow at the DMPK Modelling group. At GSK he established a quantitative mechanistic full-body modelling platform for dosed and endogenous proteins which supported drug discovery projects for mAbs, antibody fragments and other biologics across all therapy areas ranging from immunoinflammation to oncology and gene therapy. In his current job the focus remains on on cross-platform/cross-species PBPK of protein therapeutics but he is also keeping a keen eye on the developments in the field of machine learning and quantitative systems pharmacology.
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Physiologically-Based Pharmacokinetics Meets Protein Mass Spectrometry for Modelling of TMDD
Monday, October 21, 2024
9:30 AM – 10:00 AM MT