ORISE Fellow
US Food and Drug Administration
Dr. Fathima Doole holds a Ph.D. in Chemistry from the University of Arizona, where she specialized in membrane biophysics, peptide interactions, and analytical method development. Her research has focused on how variations in lipid composition affect membrane structure and mechanical properties, with an emphasis on the interaction of antimicrobial peptides with bacterial and mammalian cell membranes. Her work has provided critical insights into these interactions, which can be used to develop novel therapeutic strategies to combat infectious diseases.
Dr. Doole’s scientific passion stems from a personal experience when her newborn was diagnosed with a hospital-acquired infection. This event motivated her to pursue research aimed at addressing the growing issue of antibiotic resistance. She collaborated with the Biomedical Engineering Department at the University of Arizona to develop peptide-functionalized biomaterials designed to fight infectious diseases. In addition, her PhD work included the use of advanced biophysical techniques, such as solid-state NMR, to study peptide-lipid interactions and better understand the mechanisms of antimicrobial action.
In addition to her academic background, Dr. Doole completed a postdoctoral fellowship at the FDA, where she contributed to the development of analytical methods for dissolution and disintegration testing of immediate-release oral solid drugs. She examined the effects of excipients on dissolution profiles, which are critical for bioequivalence studies. She has proficiency in a wide range of analytical techniques, including HPLC, GC, UV-Vis spectroscopy, and solid-state NMR, making her well-suited for complex, multidisciplinary research environments.
Driven by a commitment to translational science and therapeutic innovation, Dr. Doole is eager to contribute her expertise to advancing human health, whether in postdoctoral positions, academia, or the pharmaceutical industry.