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Discovery and Basic Research
Keynote

Keynote: Modelling Prion Neurodegeneration in Human Brain Organoids; Can We Increase the Possibility of Therapeutic Success?

Wednesday, October 23, 2024
1:30 PM – 2:30 PM MT
Location:251 F

Discovery and Basic Research

Prion diseases are rare transmissible diseases affecting humans and animals. Following onset of symptoms, they are always fatal but the pathological mechanisms of disease and how to intervene to stop degeneration are still poorly understood. Therapeutics identified in animal studies have failed to translate into effective treatments in humans. Therefore, to aid discoveries that offer the best chance of therapeutic success in human disease, we developed a human cerebral organoid model of prion infection. This presentation will discuss the model, its advantages and limitations, and how it is being applied to anti-prion therapeutic research.

Learning Objectives:

  • Upon completion, participants will understand what human cerebral organoids are and how they are differentiated.
  • Upon completion, participants will understand strengths and limitations of the model, and possible approaches to overcome limitations.
  • Upon completion, participants will understand how the human cerebral organoid model has been applied to the study of human prion diseases and in what way it is being used for identifying therapeutics that might be successful in humans.