Speaker Spotlight: The Permeability Advantage of Non-Permeable Particles: Mechanistic Study and Modeling

Spotlight Speaker(s)

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  Na Li, PhD (she/her/hers)

  Assistant Professor
  University of Connecticut
  Storrs, Connecticut

Moderator(s)

• 

  Tze Ning Hiew, PhD (she/her/hers)

  Assistant Professor
  University of Iowa
  Iowa City, Iowa

Many drugs today suffer from extremely low water solubility, leading to in a negligible amount of solubilized free drug available for absorption. However, drug absorption can occur beyond its solubility limit, from drug particles as well as complexes such as micelles. These submicron- and micron-sized colloidal species function as vehicles that traverse the diffusional barrier adjacent to the intestinal wall, delivering a high payload of drug to the mucosal surface. This process was termed as the particle drifting effect. While the particle drifting effect was widely conjectured in vitro and in vivo, and is believed to be responsible for the positive food effect observed with poorly soluble drugs, accurately predicting bioavailability due to this effect remains elusive. In this presentation, we will discuss the mechanisms and extent of drug absorption beyond its solubility limit. Our results will contribute to improved formulation development and bioavailability prediction for enabling formulations, such as amorphous solid dispersions.