Symbiotic Approaches for Rapid and Cost-Effective Manufacturing of Multiparticulate Formulations

Wednesday, October 23, 2024

9:00 AM – 10:00 AM MT

Location:360 Stage #1, Exhibit Hall

Sponsored By

Partner Presentation Speaker(s)

Nitin Swarnakar, PhD (he/him/his)

NA Applications Lab Manager
BASF Corp
Tarrytown, New York
Ramesh Muttavarapu, MS

Global SME - Technical & Scieitifc Affairs
Thermo Fisher Scientific
Cincinnati, Ohio

Description: The combination of an algorithm-based virtual pharma tool, an "all-in-one" co-processed excipient, and advanced facilities can simplify the process, reduce manufacturing time and costs, and accelerate time to market. In this study, researchers developed pellets and minitablets recommended by virtual pharma assistant tool, ZoomLabTM, using individual and co-processed excipients through direct compression and wet granulation methods. Additionally, omeprazole minitablets were coated with sub- and enteric-coats using enteric compositions both with and without talc.

Learning Objectives:

Investigate the efficacy of the "All-in-one" co-processed excipient in addressing key challenges in direct compression, including flowability, compressibility, disintegration, and lubrication requirements.
Assess the robustness of delayed release through the utilization of a sub-coating of instant release polyethylene glycol-polyvinyl alcohol graft copolymer, followed enteric coating of Methacrylic acid copolymer dispersion.
Explore synergistic benefits of integrating a digital tool, "all-in-one" co-processed excipient, and talc-free enteric coating for efficient drug development , cost reduction, and accelerated time-to-market for omeprazole and other drugs