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Formulation and Delivery
Chalk Talk

Strategic Advantages of Hot Melt Extrusion for Challenging APIs in Oral Dosage Forms

Tuesday, October 22, 2024
12:30 PM – 1:30 PM MT
Location:Spotlight Stage B, Aisle 1100, Exhibit Hall

Sponsored By 
Formulation and Delivery Partner Presentation-Formulation

    Chalk Talk Presenter(s)

  • HT

    Hibreniguss Terefe, PhD

    Director, Research and Development, Clinical Development and Supply
    Catalent
    Somerset, New Jersey

Description: Hot Melt Extrusion (HME) is a powerful technology for enhancing bioavailability in oral dosage forms. This presentation challenges common misconceptions about HME, particularly for APIs with high melting points, thermal decomposition, or recrystallization issues. By exploring a systematic, phase-appropriate approach and case studies, you'll discover how HME can overcome these barriers, optimize drug delivery, and offer a strategic advantage in pharmaceutical development.

Learning Objectives:

  • Understand the fundamental principles of Hot Melt Extrusion (HME).
  • Learn a streamlined, phase-appropriate strategy for developing bioavailability-enhanced oral dosage forms.
  • Analyze case studies that debunk misconceptions about HME, especially with challenging APIs (i.e. high melting points, thermal instability, or recrystallization tendencies).