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Formulation and Delivery
Partner Presentation

Nanoparticle Formation in Impinging Jet Turbulent Reactors with HPMCAS and Random Copolymer Stabilizers

Tuesday, October 22, 2024
3:30 PM – 4:30 PM MT
Location:360 Stage #2, Exhibit Hall

Sponsored By 
Formulation and Delivery Partner Presentation-Formulation

    Partner Presentation Speaker(s)

  • Robert Prudhomme, PhD

    Professor and Founding Director
    Princeton University, dept. Chemical and Biological Engineering
    LAWRENCE TOWNSHIP, New Jersey

    Handouts

Description: Confined impinging jet (CIJ) reactors produce turbulent micromixing to create supersaturations and drive nanoparticle (NP) formation. The NP assembly is driven by the kinetics of diffusion of the core components and the stabilizer, which depends on their concentrations and molecular sizes. The assembly using amphiphilic block copolymers or lipids can be modeled quantitatively based on the relative size of the hydrophilic block and the anchoring area occupied by the hydrophobic block. We demonstrate HPMCAS, zein proteins, and methacrylate-methacrylic acid polymers as stabilizers.

Learning Objectives:

  • Understand the process of nanoparticle (NP) formation using confined impinging jet (CIJ) reactors.
  • Learn the key role of hydrophobic and hydrophilic domains in amphiphilic copolymers (such as HPMCAS, zein proteins, and methacrylate-methacrylic acid) to stabilize nanoparticle suspensions.
  • Understand the scalability of the CIJ platform from early-stage development into commercial applications.