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Manufacturing & Analytical Characterization
Partner Presentation

Extractable Leachable Analysis from Standardized Chromatography to Mass Spectral Databases

Tuesday, October 22, 2024
12:00 PM – 1:00 PM MT
Location:360 Stage #1, Exhibit Hall

Sponsored By 

Description: Lack of standardized chromatographic methods and E/L databases makes comparing data between labs challenging. In this presentation, we will cover the case study by utilizing two newly developed standards kits and its impact on the overall chromatographic separation including LC columns, organic mobile phases. buffers, gradients and flow rates. The second case study will demonstrate the use of the Agilent ChemVista library/database management software to generate new E/L database, by leveraging the imported downloadable E/L information (structures, MS/MS spectra) to create new E/L database to help identify compounds specifically detected in extracts from catheter samples.

Learning Objectives:

  • Why chromatography matters for E/L analysis.
  • How to Leverage third-party information can be used to develop custom E/L database.
  • How Custom databases can be used with NIST LCMSMS and Sirius MSMS Software.