Our research focuses on developing fundamental understanding of particle properties and their interactions at the nano and micro scales, along with translating that knowhow to innovate pharmaceutical products to satisfy unmet industry and patient needs. This presentation will cover recent work where we have leveraged fundamental advances made in our group to develop innovative powder based products by overcoming the difficulties in processing pharmaceutical powders due to their high cohesion via solventless mechanical coating of nanoparticles on their surfaces. It will include recent advances uncovering the role of fine particle agglomeration on powder behavior and power-law relationship between agglomeration, flowability, and packing where the granular Bond number could be used as a dimensionless scaling parameter. The synergistic enhancements in the blend or formulation properties will be highlighted including blend uniformity, flowability, compaction properties, and enhanced capability for direct blend direct compaction (DB-DC) tableting at either high or very low drug loadings.
Learning Objectives:
Learn about powder property enhancements relevant to continuous manufacturing (CM) for drug product manufacturing and recent developments in the area.
Upon completion, participant will be able to learn about the benefits of enhancing fine powder properties through solventless surafe modificaiton and improve the drug product continuous manufacturing.
Audience will be able to learn about the use of various models to guide their particle engineering based design of drug product formulations.
Upon completion, audience will be also able to learn about the synergystic blend and tablet property enhancements due to dry caoting of a mniority blend component.
