Executive Director Genentech south san francisco, California
Title: Potential Mechanism of Permeability Enhancement with SNAC - Insights from in-vivo studies in Rats Abstract:Oral administration is the most popular and convenient route for drug delivery, yet the success of oral drug delivery is dependent on the ADME properties of the drug. Among those ADME properties, permeability is considered one of the key attributes for successful oral drug absorption. Typically, permeability is optimized during lead optimization for small molecules. However, for large molecules (>1 KDa), the permeability is often the limiting factor for oral delivery. Hence, the utilization of permeability enhancers to improve drug oral absorption of large molecules is an important area of research in drug delivery. A multitude of data suggests that sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC) is an effective permeability enhancer. Despite its success, the mechanism of how SNAC works to enhance the oral absorption of compounds is poorly understood. In this talk, we will summarize the current understanding of how SNAC works to improve permeability using data from literature and from our labs.
Learning Objectives:
To provide an overview of current developments in peptide delivery and formulation, discussing opportunities and challenges from a characterization and permeability enhancement perspective.
To highlight current understanding of membrane permeation using permeation enhancers.
Provide future directions for understanding the role of permeation enhancers in oral delivery of peptides.
