The presentation can focus on the critical risk for weak base drugs with low solubility and how a multi-compartment system can help understand the risk, such as precipitation impacting in vivo performance. Different multicompartment transfer systems have been developed by academic and industry groups. The presenter can share the similarities and differences of each system and their learning from the system they use.
Learning Objectives:
why multi-compartment systems for low soluble weak base drugs are necessary in certain drug products
why multi-compartment systems for low soluble weak base drugs are useful to predict bioperformance of the oral dosage forms
the usage of multi-compartment dissolution systems
