Drug Delivery Strategies and Challenges for Pulmonary Nucleic Acid Delivery

In this comprehensive talk, Dr. Jenny Lam will explore the forefront of drug delivery systems with a focus on the intricate challenges and emerging strategies for nucleic acid delivery to the airways. The presentation will delve into the biological barriers that complicate effective gene therapy, including mucosal barriers, immune responses, and the cellular uptake of nucleic acids. It will highlight recent advancements in non-viral vector design, such as lipid nanoparticles and polymer-based carriers, that show promise in overcoming these hurdles. Dr. Lam will share insights from her cutting-edge research at UCL School of Pharmacy, including case studies that illustrate successful approaches to targeted delivery and expression of therapeutic genes within lung tissue. Attendees will gain an understanding of the critical factors influencing the efficiency of pulmonary gene therapy and how novel delivery platforms are being tailored to meet these challenges. The session will also touch upon regulatory considerations and the path towards clinical application, setting the stage for future innovations in the field of respiratory medicine.