PhD Candidate University of Utah, College of Pharmacy Salt Lake City, Utah
This presentation will inform on engineering a split enzyme system for targeted drug delivery. The split system is an inactive enzyme that requires binding to a target site to refold into an active enzyme. Once the binding and refolding occur, the active enzyme can convert prodrugs into active drugs specifically at the target site. The dual binding event should increase specificity for a given target and the now active enzyme can convert more drug at the intended site. The split enzyme system has the potential to increase specificity and overall disease cell death.
Learning Objectives:
Upon completion participants will be able to understand the basics and utility of split enzymes systems for drug delivery.
