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Javier Aguilera, PhD

Sr. Scientist
Moderna
Cambridge, Massachusetts

I have had a fascination with proteins since I read seminal papers on protein folding. Thus, I joined Dr. Freddy Colon’s lab at Rensselaer Polytechnic Institute (RPI) where I interrogated the effect glycosaminoglycans have on protein folding, oligomerization and fibrillation. I performed a post-doc at the Hutch where I applied my protein chemistry knowledge and evaluated global conformations that affect HIV transmission. Thereafter, I joined industry via two growth-minded experiences, one at PPD and then at BioAgilytix (BAL) in Boston. The former allowed me to leverage what I had learned in my graduate work—rigorous and robust assay development yields great studies and interpretations. At BAL I learned to apply that thinking to GCLP studies where I learned bioanalysis of biomarkers in human samples. My work as biomarker project SME and project manager drove sponsor studies to completion. I have been at Moderna for about 2 years, and I apply my knowledge to design bioanalytical methods that interrogate immunogenicity (ADAs to mRNA lipids) and pharmacodynamic (mRNA-derived proteins) evaluations. These validated bioanalytical assays are then used to evaluate clinical trials by Moderna.

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